Reaction product of propylene and synthesis gas in a hydroformylation being a sidestream during purification

Endpoint summary

Description of key information

In an oral acute toxicity test using the acute toxic class method, a LD50 > 2000 mg/kg bw was determined in female rats

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

2 000 mg/kg bw

Additional information

As required under REACh for a transported isolated intermediate, an oral acute toxicity test is available for the assessment of the acute toxicity of Zorgol 48 (1-Hexanol, 2-ethyl-, manuf. of, by-products from, distn. Residues).

 

The acute oral toxicity of Zorgol 48 was studied under GLP conditions using the acute toxic class method according to OECD test guideline 423. Two steps with the highest dose of 2000 mg/kg bw were performed with three female rats each. No mortality was observed within 14 days.

 

Consequently the oral LD50 of Zorgol 48 is higher than 2000 mg/kg bw in the rat (Colas/Laus, 2010).

In accordance with OECD TG 423, the LD50 cut-off of Zorgol 48 may be considered higher than 5000 mg/kg bw. Zorgol 48 is of low acute oral toxicity.

Justification for classification or non-classification

The acute oral LD50 in rats was > 2000 mg/kg bw (highest dose tested). The LD50 cut-off value may even be higher than 5000 mg/kg bw according to the test method used (acute toxic class method) This exceeds clearly the cut-off value for classification according to EU regulations (Directive 67/548/EEC and Regulation (EC) No 1272/2008. Classification of Zorgol 48 is not required.