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EC number: 920-427-4
CAS number: -
Tables with detailed test results are
included under "Attached background material".
In a reverse gene mutation assay in
bacteria, (Ames test) under GLP conditions according to OECD test
guideline 471, five strains of S. typhimurium (TA 97a, TA 98, TA 100, TA
102, and TA 1535) were exposed to the test substance Zorgol 48
(1-Hexanol, 2-ethyl-, manuf. of, by-products from, distn. residues) in
ethanol at concentrations of 50, 150, 500, 1501, and 5002 µg/plate
(experiment 1, plate incorporation assay) and at concentrations of 312,
624, 1248, 2496, and 4992 µg/plate (experiment 2: pre-incubation assay)
in the presence and absence of mammalian metabolic activation (S9-mix
from Aroclor induced male rat liver).
Zorgol 48 was tested up to a limit
concentration of 5000 µg/plate. It did not show any cytotoxicity up to
this concentration. Negative controls did not show a response above
background and positive controls induced the appropriate responses in
the corresponding strains.
Zorgol 48 did not increase the number
of revertants in any of the tester strains in either experiment with and
without metabolic activation. There was no evidence of induced mutant
colonies over background. The test item is stated as not
mutagenic under test conditions (Paulus/Laus, 2010).
This study is classified as
acceptable. It satisfies the requirement of OECD TG 471 and EU Method
B.13/14 for in vitro mutagenicity (bacterial reverse gene mutation)
tests without restriction.
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