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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature available

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
Author:
Gesellschaft deutscher Chemiker
Year:
1990
Bibliographic source:
Beratergremium für umweltrelevante Altstoffe (BUA), BUA-Stoffbericht 55
Reference Type:
study report
Title:
Unnamed
Year:
1972

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
3-chloro-p-toluidine
EC Number:
202-446-3
EC Name:
3-chloro-p-toluidine
Cas Number:
95-74-9
IUPAC Name:
3-chloro-4-methylaniline

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Remarks on duration:
further: 7 hours and 4 hours daily on five consecutive days
Concentrations:
1.3, 1.4, and 1.76 mg/m³ air
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC0
Effect level:
> 1.76 mg/m³ air (analytical)
Based on:
test mat.
Exp. duration:
4 h
Sex:
male
Dose descriptor:
LC0
Effect level:
> 1.76 mg/m³ air (analytical)
Based on:
test mat.
Exp. duration:
7 h
Sex:
male
Dose descriptor:
LC0
Effect level:
> 1.76 mg/m³ air (analytical)
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: daily on five consecutive days
Mortality:
No mortality occurred.
Clinical signs:
other: At no time point of exposure the rats showed intoxication symptoms.

Applicant's summary and conclusion