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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature available

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
Author:
Gesellschaft deutscher Chemiker
Year:
1990
Bibliographic source:
Beratergremium für umweltrelevante Altstoffe (BUA), BUA-Stoffbericht 55
Reference Type:
study report
Title:
Unnamed
Year:
1972

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
3-chloro-p-toluidine
EC Number:
202-446-3
EC Name:
3-chloro-p-toluidine
Cas Number:
95-74-9
IUPAC Name:
3-chloro-4-methylaniline

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Remarks on duration:
further: 7 hours and 4 hours daily on five consecutive days
Concentrations:
1.3, 1.4, and 1.76 mg/m³ air
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC0
Effect level:
> 1.76 mg/m³ air (analytical)
Based on:
test mat.
Exp. duration:
4 h
Sex:
male
Dose descriptor:
LC0
Effect level:
> 1.76 mg/m³ air (analytical)
Based on:
test mat.
Exp. duration:
7 h
Sex:
male
Dose descriptor:
LC0
Effect level:
> 1.76 mg/m³ air (analytical)
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: daily on five consecutive days
Mortality:
No mortality occurred.
Clinical signs:
other: At no time point of exposure the rats showed intoxication symptoms.

Applicant's summary and conclusion