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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only secondary literature

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
Author:
Gesellschaft deutscher Chemiker
Year:
1990
Bibliographic source:
Beratergremium für umweltrelevante Altstoffe (BUA), BUA-Stoffbericht 55
Reference Type:
study report
Title:
Unnamed
Year:
1972

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
3-chloro-p-toluidine
EC Number:
202-446-3
EC Name:
3-chloro-p-toluidine
Cas Number:
95-74-9
IUPAC Name:
3-chloro-4-methylaniline

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Type of coverage:
not specified
Vehicle:
polyethylene glycol
Details on dermal exposure:
TEST SITE
- Area of exposure: abdomen
Duration of exposure:
4 hours or 7 days
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
765 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 4 hour application
Sex:
male
Dose descriptor:
LD50
Effect level:
336 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 7 day application
Mortality:
Animals died within one to two days.
Clinical signs:
Cyanosis, labor respiration and sedation was seen 6 hours after application. Animals which did not die recovered within 4 to 7 days.
Other findings:
The highest dose tested without lethal effects was 118 mg/kg bw and the highest dose without symptoms was 59 mg/kg bw.

Applicant's summary and conclusion