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EC number: 201-756-6
CAS number: 87-60-5
Skin: not irritating (Non-GLP OECD Guideline Study 404, BASF, 85/48, 1985)Eye: causes serious eye damage (Non-GLP OECD Guideline Study 405, BASF, 85/48, 1985)
are valid in vivo data available for the assessment of the skin and eye
irritation potential of 3 -chloro-toluidine.
In a primary dermal irritation study (OECD 404,
BASF, 85/48, 1985), 3 Vienna White rabbits (male and females) were
dermally exposed to 0.5 mL of 3-chloro-o-toluidine for 4 hours under
semiocclusive conditions. Animals then were observed for 3 days.
Irritation was scored by the method of Draize as described in the OECD
guideline 404. The mean score for the 24, 48 and 72 h reading for
erythema was 0.6 and for edema was 0.1. The skin reactions observed were
reversible until the end of the observation period on day 3. In this
study, the test substance is not a dermal irritant.
Substance Directive (67/548/EEC)
studies are considered reliable and suitable for classification purposes
under 67/548/EEC. As
a result the substance is not
considered to be classified for skin irritation but is considered to be
classified for eye irritation (R41) under Directive 67/548/EEC, as
amended for the 28th time in Directive 2001/59/EC.
Labelling, and Packaging Regulation (EC) No. 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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