Registration Dossier
Registration Dossier
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EC number: 938-871-2 | CAS number: 6613-31-6
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.5400 (Algal Toxicity, Tiers I and II) (January 2012)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 8-(butan-2-yl)-5,6,7,8-tetrahydroquinoline
- EC Number:
- 938-871-2
- Cas Number:
- 6613-31-6
- Molecular formula:
- C13H19N
- IUPAC Name:
- 8-(butan-2-yl)-5,6,7,8-tetrahydroquinoline
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
The biological results of the study were as follows (based on mean measured concentrations of the test item GR-50-0572): 72 hours 96 hours Effect concentration [mg/L] Growth rate Yield Growth rate Yield EC50 (95% CI) Direct Analysis 3.4 (3.1-3.7) 1.2 (1.1-1.4) 3.1 (3.0 – 3.3) 1.3 (1.1 – 1.4) Corrected for Algal Uptake 3.5 (3.3-3.8) 1.3 (1.2-1.5) 3.5 (3.3-3.6) 1.5 (1.3-1.6) EC20 (95% CI) Direct Analysis 1.5 (1.4-1.6) 0.51 (0.42-0.60) 1.7 (1.6 – 1.8) 0.65 (0.53 – 0.76) Corrected for Algal Uptake 1.5 (1.4-1.7) 0.54 (0.44-0.63) 1.9 (1.8-2.0) 0.76 (0.63-0.88) EC10 (95% CI) Direct Analysis 0.97 (0.83-1.1) 0.33 (0.24-0.40) 1.3 (1.1 – 1.4) 0.46 (0.35 – 0.56) Corrected for Algal Uptake 1.0 (0.87-1.1) 0.34 (0.26-0.43) 1.4 (1.3-1.5) 0.54 (0.42-0.65) NOEC Direct Analysis n.d. n.d. 0.38 0.38 Corrected for Algal Uptake n.d. n.d. 0.45 0.45 LOEC Direct Analysis 0.20 0.20 0.71 0.71 Corrected for Algal Uptake 0.21 0.21 0.83 0.83
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