Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: summary report. Although the study was conducted before Good Laboratory Practices were published, the study appears to have been conducted using appropriate methods and to have been fully reported.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- ROBUST SUMMARY OF NFORMATION ON Distillate Fuels
- Author:
- American Petroleum Institute
- Year:
- 2 003
- Bibliographic source:
- ROBUST SUMMARY OF NFORMATION ON Distillate Fuels 42-43
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not specified
- Principles of method if other than guideline:
- The method is draize Test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- API 79-6
- IUPAC Name:
- API 79-6
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 14 days
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- ca. 6.81
- Remarks on result:
- other: See table information
Any other information on results incl. tables
At 24 hours the skin of all rabbits was very irritated. Blisters had formed and some of these had opened.
At 72 hours the sites were still very irritated and open sores were observed in 2 rabbits.
At day 7 scabs had formed at most test sites
At day 14 the skin was healing but was still dry and flaky and there had been no hair growth.
Average scores for erythema and edema are listed below
| Exposure time (h) | Average score | |
| Erythema | ||
| Intact skin | 24 | 4.0 |
| 72 | 3.83 | |
| Abraded skin | 24 | 4.0 |
| 72 | 3.83 | |
| Edema | ||
| Intact skin | 24 | 3.0 |
| 72 | 2.92 | |
| Abraded skin | 24 | 3.0 |
| 72 | 2.67 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
