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EC number: 701-379-1 | CAS number: -
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2007-10-29 to 2007-10-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study is regarded as reliable without restrctions because it was conducted in accordance with GLP regulation and guideline. For read across justification please refer to IUCLID section 13.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- yes
- Test temperature:
- 25 °C
- Details on study design: HPLC method:
- Apparatus
HPLC system: Merck-Hitachi LaChrom HPLC system:
D-7000 Interface, No.: 1126-175
L-7100 HPLC pump, No.: 1388-056
L-7200 Autosampler, No.: 1380-033
L-7400 UV Detector, No.: 1374-025
L-7360 Column Oven, No.: 00118060
L-7614 Degasser, No.: 144116A0094
Balance: BP 221 S Sartorius, No.: 11809117
Ultrasonic bath: ELMA Elmasonic S300H, No.:10890105
PH meter: Radelkisz OP-208, No.:1701
Water purification system: MILLIPORE, DIRECT Q3,
FOMNO 7334I
Stationary Phase
Analytical column: LiChrospher 100 CN (5 µm) 250x4 No.: 638212
HPLC Conditions
Detector: UV at 230 nm
Flow: 0.8 mL/min.
Injection volume: 5 µL
Temperature: 25 °C
Mixtures, Solutions
Mobil Phase: Methanol : Water and Trifluoroacetic acid mixture with the ratio 55 : 45 : 0.1(v/v)
Reaction products of IPDA with bisphenol A diglycidylether (BADGE): 1 mg/mL Reaction products of IPDA with bisphenol A diglycidylether (BADGE) was dissolved in Methanol
Reference Substances
Eight chemicals for which log Koc has been reported were used to calibrate the elution time in units of log Koc.
Reference substances used for calibration:
Sodium nitrate = T0
Acetanilide = 1.25
Methyl benzoate = 1.80
Isoproturon = 1.86
Linuron = 2.59
Naphthalene = 2.75
Pyrazophos = 3.65
Phenantrene = 4.09
DDT = 5.63 - Key result
- Type:
- Koc
- Value:
- 65 860 L/kg
- Key result
- Type:
- log Koc
- Value:
- 4.82 dimensionless
- Details on results (HPLC method):
- The adsorption coefficient Koc was determined based on a calibration curve using 8 reference items. The capacity factors k’ were calculated from the dead time and retention times of the reference substances. The log k’ data of the reference substances were plotted against their log Koc values.
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the course of this study the adsorption coefficient (Koc) of Reaction products of IPDA with bisphenol A diglycidylether (BADGE) was estimated, using high performance liquid chromatography.
The log Koc of Reaction products of IPDA with bisphenol A diglycidylether (BADGE) was found to be 4.82.
The quality criteria were met, as values of log Koc derived from individual measurements fell within a range of ± 0.25 log units and the correlation coefficient R was >0.95.
The estimated log Koc: 4.82
The estimated Koc: 65860 - Executive summary:
Estimation of the Adsorption Coefficient (Koc) of Reaction products of IPDA with bisphenol A diglycidylether (BADGE)according to OECD 121 and EU method C.19 was performed. In the course of this study the adsorption coefficient (Koc) of Reaction products of IPDA with bisphenol A diglycidylether (BADGE) was estimated, using high performance liquid chromatography. The estimated log Koc is 4.82 and the estimated Koc is 65869, respectively.
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- from 2007-10-29 to 2007-10-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study is regarded as reliable without restrctions because it was conducted in accordance with GLP regulation and guideline. For read across justification please refer to IUCLID section 13.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- 25 °C
- Details on study design: HPLC method:
- Apparatus
HPLC system: Merck-Hitachi LaChrom HPLC system:
D-7000 Interface, No.: 1126-175
L-7100 HPLC pump, No.: 1388-056
L-7200 Autosampler, No.: 1380-033
L-7400 UV Detector, No.: 1374-025
L-7360 Column Oven, No.: 00118060
L-7614 Degasser, No.: 144116A0094
Balance: BP 221 S Sartorius, No.: 11809117
Ultrasonic bath: ELMA Elmasonic S300H,No.:10890105
PH meter: Radelkisz OP-208, No.:1701
Water purification system: MILLIPORE, DIRECT Q3,FOMNO 7334I
Stationary Phase
Analytical column: LiChrospher 100 CN (5 µm) 250x4 No.: 638212
HPLC Conditions
Detector: UV at 230 nm
Flow: 0.8 mL/min.
Injection volume: 5 µL
Temperature: 25 °C
Mixtures, Solutions
Mobil Phase: Methanol : Water and Trifluoroacetic acid mixture with the ratio 55 : 45 : 0.1(v/v)
Reaction products of MXDA with bisphenol A diglycidylether (BADGE): 1 mg/mL Reaction products of MXDA with bisphenol A diglycidylether (BADGE) was dissolved in Methanol
Reference Substances
Eight chemicals for which log Koc has been reported were used to calibrate the elution time in units of log Koc.
Reference substances used for calibration:
Sodium nitrate = T0
Acetanilide = 1.25
Methyl benzoate = 1.80
Isoproturon = 1.86
Linuron = 2.59
Naphthalene = 2.75
Pyrazophos = 3.65
Phenantrene = 4.09
DDT = 5.63 - Key result
- Type:
- Koc
- Value:
- 9 805 L/kg
- Key result
- Type:
- log Koc
- Value:
- 3.99 dimensionless
- Details on results (HPLC method):
- The adsorption coefficient Koc was determined based on a calibration curve using 8 reference items. The capacity factors k’ were calculated from the dead time and retention times of the reference substances. The log k’ data of the reference substances were plotted against their log Koc values.
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the course of this study the adsorption coefficient (Koc) of Reaction products of MXDA with bisphenol A diglycidylether (BADGE) was estimated, using high performance liquid chromatography.
The log Koc of Reaction products of MXDA with bisphenol A diglycidylether (BADGE) was found to be 3.99.
The quality criteria were met, as values of log Koc derived from individual measurements fell within a range of ± 0.25 log units and the correlation coefficient R was >0.95.
The estimated log Koc: 3.99
The estimated Koc: 9805 - Executive summary:
Estimation of the Adsorption Coefficient (Koc) of Reaction products of MXDA with bisphenol A diglycidylether (BADGE) according to OECD 121 and EU method C.19 was performed. In the course of this study the adsorption coefficient (Koc) of Reaction products of MXDA with bisphenol A diglycidylether (BADGE) was estimated, using high performance liquid chromatography. The estimated log Koc is 3.99 and the estimated Koc is 9805, respectively.
Referenceopen allclose all
Description of key information
Based on a read-across approach using data obtained for Reaction products of IPDA with bisphenol A diglycidylether (BADGE) and Reaction products of MXDA with bisphenol A diglycidylether (BADGE) the log Koc for the asymmetrical adduct Reaction product of Bisphenol A diglycidylether (BADGE) with IPDA and MXDA was estimated at 4.82 (worst-case scenario).
Key value for chemical safety assessment
- Koc at 20 °C:
- 65 860
Additional information
No data was available for the asymmetrical epoxy amine adduct Reaction Product of Bisphenol A diglycidylether (BADGE) with IPDA and MXDA. Based on a read-across approach from symmetrical epoxy amine adducts Reaction products of IPDA with bisphenol A diglycidylether (BADGE) and Reaction products of MXDA with bisphenol A diglycidylether (BADGE), the adsorption coefficient was determined in a range of log Koc of 3.99 to 4.82, respectively Koc of 9805 to 65860.
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