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EC number: 400-600-6 | CAS number: 71868-10-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: assessment
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Because of limited data (which are provided by ECHA) it is difficult to make a full toxicokinetic assessment.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- No information
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guidance on information requirements and chemical safety assessment, Chapter R.7c: Endpoint specific guidance, R.7.12 Guidance on Toxicokinetics
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
- EC Number:
- 400-600-6
- EC Name:
- 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
- Cas Number:
- 71868-10-5
- Molecular formula:
- C15H21NO2S
- IUPAC Name:
- 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
Constituent 1
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Oral/GI absorption
With a moderate log P value (3.09), substance has relative low water solubility (17.9 mg/L).
Substance is considered to have oral/GI absorption because of not only its log P value but also signs of systemic toxicity (acute toxicity oral: LD50 = 1984 mg/kg bw).
However, the oral toxicity data showing the LD50 being 1984 mg/kg bw will gives no indication of the amount of substance that has been absorbed. It is to be expected that the oral bioavailability and the systemic exposure of the substance will be relatively low.
Respiratory absorption – Inhalation
Substance has the potential to be inhaled. Because of the relatively large particle size uptake via the lungs is not expected.
Dermal absorption
With low water solubility, dermal absorption of the substance is anticipated to be low. Since Log P value favours dermal absorption, it is to be expected that substance may penetrate the skin to some extent. - Details on distribution in tissues:
- System effects were observed in the 90-day oral toxicity study with paresis of the hind limbs, loss of hair, dim, opaque eyes, also small effects on liver-derived enzymes were observed in the higher dose group. It is therefore possible to conclude that the substance is transported. Despite the low water solubility , substance is considered to have a relatively low adsorption coefficient. Accumulation in fat or in other tissues is unlikely. The plasma protein binding is expected to be high.
- Details on excretion:
- Due to its low molecular weight (below 300), in the case absorption of substance occurs, substance will be excreted via bile and/or urine.
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- In the case absorption of substance occurs, both the saturated and the unsaturated ring may undergo extensive hydroxylation, followed by rapid sulfation or glucuronidation. Furthermore, S-demethylation is anticipated. Substance will be extensively metabolised in the liver and rapidly excreted via bile and/or urine. Therefore, accumulation in the body during prolonged exposure will be very low.
Applicant's summary and conclusion
- Conclusions:
- Based on the expected kinetic behaviour in the body, there is sufficient evidence that some oral/GI absorption takes place and there is likely to be adaptive changes to the animals following transportation and possible metabolism. Because of the relatively large particle size uptake via the lungs is not expected. Dermal absorption is anticipated to be low thanks to low water solubility. If absorption occurs, substance will be extensively metabolised in the liver. Because of its lower molecular weight (< 300) and slight solubility in water (17.9 mg/L), substance is favourable for urinary excretion. Substance was predicted to has no bioaccumulation potential.
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