Registration Dossier
Registration Dossier
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EC number: 203-311-1 | CAS number: 105-58-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1966
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Older study with limited documentation
Data source
Reference
- Reference Type:
- publication
- Title:
- Über enzymatische Spaltung und Stoffwechsel von Umsetzungsprodukten des Pyrokohlensäurediäthylesters mit Bestandteilen von Lebensmitteln
- Author:
- Lang K, Fingerhut M, Krug E, Reimold W & Pauli O
- Year:
- 1 966
- Bibliographic source:
- Z. Ernährungswiss 6, 219-228
Materials and methods
- Objective of study:
- toxicokinetics
Test material
- Reference substance name:
- Diethyl carbonate
- EC Number:
- 203-311-1
- EC Name:
- Diethyl carbonate
- Cas Number:
- 105-58-8
- Molecular formula:
- C5H10O3
- IUPAC Name:
- diethyl carbonate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The incubation of diethyl carbonate with homogenates of bovine kidney or mucous membrane from the small intestine resulted in an enzymatic cleavage of the substance. The increase in pressure caused by liberated CO2 was measured manometrically in a Warburg apparatus.
- Executive summary:
The incubation of diethyl carbonate with homogenates of bovine kidney or mucous membrane from the small intestine resulted in an enzymatic cleavage of the substance. The increase in pressure caused by liberated CO2 was measured manometrically in a Warburg apparatus.
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