Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 633-172-6 | CAS number: 66415-55-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Oral
In an acute toxicity test, according to OECD guideline 423, 3 females received 2000 mg/kg bw and 6 females received 300 mg/kg bw Aminopropyl Vinyl Ether under standardized conditions (BASF AG, 2013). The animals were observed for 14 d, necropsy was performed even with the survivors. The LD50 is >300 and <2000 mg/kg bw for female rats. None of the females in the 300 mg/kg bw dose group died during the observation period, but 3/3 animals of the 2000 mg/kg bw died within hour 0 after administration. Clinical observations in the 300 mg/kg bw administration group: impaired general state, piloerection, pronounced dyspnea, exophthalamos, lacrimation and salivation. Clinical observations in the 2000 mg/kg bw administration group revealed poor general state, pronounced dyspnoea, salivation and piloerection and were observed. The body weight of three animals in both 300 mg/kg dose groups decreased during the first post-observation week, but increased normally during the second post-observation week. At gross necropsy following macroscopic finding were observed in the 2000 mg/kg group: severe swelling of the stomach mucosa, dark red discoloration of the stomach content, extensive bleeding in the glandular stomach and forestomach, dark red discoloration of the small intestine and its content, spotted discoloration of the liver and congestion in the kidneys. No macroscopic pathologic abnormalities were noted at termination of the study in the surviving animals (300 mg/kg bw).
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available experimental test data are considered reliable and suitable for the purpose of classification. Therefore Aminopropyl Vinyl Ether has to be classified according to EU: Xn; R22
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data are considered reliable and suitable for the purpose of classification. Therefore Aminopropyl Vinyl Ether has to be classified according to GHS: Category 4, H302
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
