Registration Dossier
Registration Dossier
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EC number: 205-736-8 | CAS number: 149-30-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A NTP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 140-30-4
- IUPAC Name:
- 140-30-4
- Reference substance name:
- Mercaptobenzothiazole
- IUPAC Name:
- Mercaptobenzothiazole
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 13 weeks
- Frequency of treatment:
- 5 days/week
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- LOAEL
- Effect level:
- 750 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Dose descriptor:
- NOAEL
- Effect level:
- 375 mg/kg bw/day (nominal)
- Based on:
- test mat.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
At 3000 mg/kg-day, all of the rats died. Due to the high mortality, the initial study was terminated and a second one was conducted using the same testing protocol with the omission of the highest dose level (3000 mg/kg-day). In the second study, no treatment-related deaths occurred. Body weight gains were lower than those in the vehicle control groups in males at 1500 mg/kg-day and in females at 750 or 1,500 mg/kg-day. Hepatomegaly occurred at 750 and 1500 mg/kg-day in males and at all doses in females; however, no microscopic pathologic changes were noted in any tissue. LOAEL = 750 mg/kg-day (based on decreased body weight gain in females) NOAEL = 375 mg/kg-day
Applicant's summary and conclusion
- Conclusions:
- LOAEL = 750 mg/kg-day (based on decreased body weight gain in females) NOAEL = 375 mg/kg-day
- Executive summary:
Mercaptobezothiazole LOAEL = 750 mg/kg-day (based on decreased body weight gain in females) NOAEL = 375 mg/kg-day in 13 weeks study.
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