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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
genetic toxicity in vitro
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Zeiger E et al
Year:
1987
Bibliographic source:
Environ Mutagen 9 (3): 269-80

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
there is no guideline available
GLP compliance:
not specified
Type of assay:
in vitro mammalian chromosome aberration test

Test material

Constituent 1
Chemical structure
Reference substance name:
4-nitrobenzoic acid
EC Number:
200-526-2
EC Name:
4-nitrobenzoic acid
Cas Number:
62-23-7
Molecular formula:
C7H5NO4
IUPAC Name:
4-nitrobenzoic acid

Results and discussion

Test results
Species / strain:
Chinese hamster Ovary (CHO)

Any other information on results incl. tables

4-nitrobenzoic acid (NBA) was for mutagenicity in Salmonella and for its ability to induce chromosome aberrations and sister chromatid exchanges (SCE) in cultured Chinese hamster ovary (CHO) cells. NBA was positive in Salmonella and CHO cells.

Applicant's summary and conclusion

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