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Administrative data

Description of key information

-acute toxicity, oral: BASF AG 10A0407/071055, 2008-rat: LD50 > 2000 mg/kg bw; practically nontoxic
-acute toxicity, dermal: no data
-acute toxicity, inhalative: no data

Key value for chemical safety assessment

Additional information

Single doses of 2000 and 300 mg/kg body weight of the test material or a test material preparation in olive oil Ph.Eur./DAB were given to 3 administration groups of three fasted female animals each, (300 mg/kg in 3 females, 2000 mg/kg in 6 females) by gavage in a sequential manner. No mortality occurred in the administration groups. Clinical observation in the 2000 mg/kg administration groups revealed impaired general state, dyspnoea, piloerection, exsiccosis, respiration sounds and reduced or no feces. Findings were observed from hour 2 through to study day 2 after administration. No clinical signs and findings were observed in the 300 mg/kg administration group. The mean body weights of the administration groups increased throughout the study period. No macroscopic pathologic abnormalities were noted in the animals of the administration groups examined on the last day of observation. Under the conditions of this study the median lethal dose of Ethyl difluoroacetate after oral administration was found to be greater than 2000 mg/kg body weight in rats.

Justification for classification or non-classification

Since the median lethal dose (LD50) of Ethyl difluoroacetate after oral administration was found to be greater than 2000 mg/kg body weight in rats, the test substance ethyl difluoroacetate does not need to be classified as toxic.

According to 67/547/EEC Annex I and EC/1272/2008 Annex VI Ethyl difluoroacetate is also not classified.

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