Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate

Bioaccumulation: aquatic / sediment

Administrative data

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

October 1983-April 1984

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted in accordance with the Good Laboratory Practice standards of Mitsubishi-kasei Institute of Toxicological and Environmental Sciences, Japan. The study followed the OECD305E Guideline with some deviations.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1984

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 305 E (Bioaccumulation: Flow-through Fish Test)

Deviations:

yes

Remarks:

sampling time of acetone application solution; extra analyses of test water samples

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate

EC Number:

932-389-6

Molecular formula:

C23H19ClF3NO3

IUPAC Name:

Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate

Applicant's summary and conclusion

Conclusions:

The study is considered to be reliable with restrictions. The results are sufficiently detailed and unambiguous as to be adequate for risk assessment, classification and labeling.

Executive summary:

Daphnia pulex and carp (Cyprinus carpio) were exposed to cyhalothrin in static water systems, with or without soil. Toxicity in the following four test systems was determined with various cyhalothrin application methods: 1. Water only, application to the water 2. Water with undisturbed soil layer, application to the water phase 3. Water with stirring to suspend the soil layer, application to the water phase with suspended material 4. Water with undisturbed soil layer, application to the soil before adding the water.

For both Daphnia pulex and carp, the acute toxicity to cyhalothrin over 72 hours based on nominal initial concentrations in the water phase was reduced when soilwas included in the test system. The 72 h EC50 and LC50 values for both species were increased by pproximately 3 times with an undisturbed soil layer, 6-40 times where the soil was suspended in the water and 71-175 times when the cyhalothrin was applied to the soil before adding the overlying water. These data indicate that, under environmentally realistic conditions in which soil or sediment is present, exposure will be substantially reduced, thereby reducing the apparent toxicity of the compound.