Registration Dossier
Registration Dossier
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EC number: 932-389-6 | CAS number: -
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- January 1989 - February 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed under GLP and followed the OECD Guidelines. The study is considered reliable without restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
- EC Number:
- 932-389-6
- Molecular formula:
- C23H19ClF3NO3
- IUPAC Name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
Constituent 1
Test animals
- Species:
- mouse
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The study is considered to be reliable.
- Executive summary:
Cyhalothrin has been evaluated for its ability to induce micronuc1eated polychromatic erythrocytes in the bone marrow of C57BL/6JfCD-l/Alpk mice. Cyhalothrin was given as a single oral dose to groups of five male mice at dose levels of 13.5 or 21.6mg/kg and to groups of five female mice at dose levels of 15.5 or 24.8mg/kg; these being 50% and 80% of the median lethal dose as determined over a four day period. Bone marrow samples were taken for analysis 24, 48 and 72 hours after dosing.
An examination of the incidence of micronucleated polychromatic erythrocytes showed a negative response for cyhalothrin at both of the dose levels tested. The positive control substance, cyclophosphamide dosed at 65mg/kg, gave significantly increased frequencies of micronucleatect polychromatic erythrocytes at the 24 hour sampling time, thus demonstrating the sensitivity of the test system to a known clastagen.
It is therefore concluded that cyhalothrin is not clastagenic in this assay.
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