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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
August 2006
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Qualifier:
according to guideline
Guideline:
EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
GLP compliance:
no
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
6-bromo-4-phenyl-3,4-dihydro-2H-1-benzopyran-2-one
EC Number:
923-250-0
Cas Number:
156755-23-6
Molecular formula:
C15H11BrO2
IUPAC Name:
6-bromo-4-phenyl-3,4-dihydro-2H-1-benzopyran-2-one

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 0.5% Methylcellulose
Doses:
10 mL/kg
No. of animals per sex per dose:
3 females => 300 mg/kg
3 females => 2000 mg/kg
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw

Any other information on results incl. tables

No mortality and no clinical signs were noted during the study.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 oral rat > 2000 mg/kg