Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for selection of skin irritation / corrosion endpoint:
In OECD (2004), hydrophilic pyrogenic or precipitated silica were tested by exposing rabbits to 0.19 g or 0.5 g of dry or moistened test item under occlusive conditions for 4 or 24 hours. These synthetic amorphous silica were not irritating to skin under experimental conditions. However, these compounds may produce skin dryness following prolonged and repeated exposure

Justification for selection of eye irritation endpoint:
In OECD (2004), all synthetic amorphous silica products tested as a powder (0.1 g) have shown no or only weak and transient irritating effects on the conjunctivae of the eyes of rabbits with the iris and cornea not affected at all. In conclusion, synthetic amorphous silica are not irritating to eyes under experimental conditions.

Justification for classification or non-classification