Registration Dossier
Registration Dossier
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EC number: 609-201-3 | CAS number: 36062-04-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
- Cas Number:
- 36062-04-1
- Molecular formula:
- C21H24O6
- IUPAC Name:
- 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Sex:
- male
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Concentration / amount:
- 0.25%
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Concentration / amount:
- 0.25%
- No. of animals per dose:
- 10 + 5 control
Results and discussion
Any other information on results incl. tables
Information provided in full study report
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information
- Executive summary:
In order to assess the allergenic potential of Tetrahydrocurcuminoids, the Maximization Test was performed in 10 treated (male) and 5 control (male) Albino guinea Pigs, in accordance with OECD Guideline No. 406.
The intradermal induction of sesitization in the test group was performed in thedorsal skin from the scapular regation witn a 0.25% dilution of the test item in popylen glycol and in an emulsion of Freund's Complete Adjuvant (FCA)/Physiological saline. The epidermal induction of sensitization was conducted for 48 hours under occlusion with the test item at 100% one week after the intradermal induction. The animals of the controle group were intradermally induced with propylene glycol and FCA/physiological saline and epidermally induced with 80% ethanol under occlusion.
Two weeks after epidermal nduction the test and the control animals were challenged by epidermal application of the test item at 50% in acetone alone under occlusion. Cutaneous reactions were evaluated at 24 and 48 hours after removal of the dressing.
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