Registration Dossier
Registration Dossier
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EC number: 701-248-9 | CAS number: -
Carcinogenicity
Administrative data
Description of key information
No carcinogenicity study is available but there is information from a qualitative and quantitative understanding of the toxicological properties of the ether linked NLP polyols that a weight of evidence approach was used to decide on classification.
Key value for chemical safety assessment
Justification for classification or non-classification
Although no carcinogenicity study is available, it is concluded that carcinogenicity is not an endpoint of concern. There is no evidence from the in vitro genotoxicity studies on basis from ´read across´from Sucrose, PO; Triethanolamine, PO; Glycerin, PO and Glucitol, PO that the target substance is able to induce mutagenicity. Furthermore the available repeated dose toxicity study (´read across´ from Triethanolamine, PO) gives no evidence of serious or severe toxicity up to and including 1000 mg/kg (NOEL= 1000 mg/kg). Using the weight of evidence, it is concluded that carcinogenicity is not an endpoint of concern.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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