Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

For detailed data on DNEL/DMEL values assigned for the substance, please, refer Chemical Safety Assessment Report (CSR)

Health effects ofReaction mass of 2,6-di-tert-butyl-p-cresol, 4,6-di-tert-butyl-o-cresol and 2,6-di-tert-butylphenol componentshave been studied comprehensively and reviewed by the National Toxicology Program (NTP, 1979), the World Health Organisation (WHO, 1987), the International Agency for Research on Cancer (IARC, 1986, 1987), the Joint FAO/WHO Expert Committee on Food Additives (JECFA, 1996), the OECD High Production Volume chemicals evaluation programme (OECD, SIDS, 2005), the European Food Safety Authority (EFSA) Panel on Food Additives and Nutrient Sources added to Food (EFSA, 2012). Because these reports have undergone several levels of technical review, it is assumed for the purpose of the present CSR that any referenced toxicity data cited in them are also reliable.

General Population - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard via oral route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

For detailed data on DNEL/DMEL values assigned for the substance, please, refer Chemical Safety Assessment Report (CSR).

Health effects ofReaction mass of 2,6-di-tert-butyl-p-cresol, 4,6-di-tert-butyl-o-cresol and 2,6-di-tert-butylphenol componentshave been studied comprehensively and reviewed by the National Toxicology Program (NTP, 1979), the World Health Organisation (WHO, 1987), the International Agency for Research on Cancer (IARC, 1986, 1987), the Joint FAO/WHO Expert Committee on Food Additives (JECFA, 1996), the OECD High Production Volume chemicals evaluation programme (OECD, SIDS, 2005), the European Food Safety Authority (EFSA) Panel on Food Additives and Nutrient Sources added to Food (EFSA, 2012). Because these reports have undergone several levels of technical review, it is assumed for the purpose of the present CSR that any referenced toxicity data cited in them are also reliable.