Registration Dossier
Registration Dossier
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EC number: 938-094-9 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The toxicokinetics ofReaction mass of 2,6-di-tert-butyl-p-cresol, 4,6-di-tert-butyl-o-cresol and 2,6-di-tert-butylphenolmajor component, BHT, have been comprehensively reviewed and reported elsewhere (WHO, 1964, 1986, 1999; OECD SIDS, 2005; EFSA, 2012).
The uptake, metabolism, distribution and elimination of BHT was investigated in a number ofin vivoandin vitrostudies in animals providing similar results. Experiments in animal test systems demonstrated that BHT was readily absorbed via the gastrointestinal tract and metabolised in test animals.
Higher concentrations of BHT were observed in the adipose tissue and liver. However, no bioaccumulation was seen for BHT.
BHT is metabolized by cytochrome P450 (CYP) enzymes. The metabolites observed include ester glucuronide and ether glucuronide. BHT is excreted with urine (main elimination route) and faeces.
No experimental or human data were located on toxicokinetics of 2,6-di-tert-butylphenol. Based on the structural properties of this chemical, it is possible to assume that 2,6-di-tert-butylphenol may be absorbed and to be metabolised like other di-alkylphenols.
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