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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Only few data on test method reported.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
Principles of method if other than guideline:
An acute oral toxicity test was performed in 8 rats per groups. 5 concentrations were tested. The post-observation period was 7 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzophenone
EC Number:
204-337-6
EC Name:
Benzophenone
Cas Number:
119-61-9
Molecular formula:
C13H10O
IUPAC Name:
benzophenone
Details on test material:
- Name of test material (as cited in study report): Benzophenone

Test animals

Species:
mouse
Strain:
Swiss
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 19-25 g
- Fasting period before study: 16 hours

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: gum arabicum
Doses:
5 test concentrations. No details available.
No. of animals per sex per dose:
8 animals per dose
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: Yes
- Other examinations performed: clinical signs
Statistics:
Probit analysis with confidence limits.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 2 895 mg/kg bw
Based on:
test mat.
Clinical signs:
In lethal doses, benzophenone induced sedation, progressive depression of motor activity, unstable gait, tremors and respiratory impairment.
Gross pathology:
No gross lesions detected at necropsy.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 in rats was determined to be ca. 2895 mg/kg bw.
Executive summary:

An acute oral toxicity test was performed with benzophenone. The test substance was administered to 8 mice per group by oral gavage as single application. Necropsy was performed 7 days after administration. Clinical signs at lethal doses were sedation, progressive depression of motor activity, unstable gait, tremors and respiratory impairment. The LD50 in rats was determined to be ca. 2895 mg/kg bw.

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