Registration Dossier
Registration Dossier
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EC number: 202-860-4 | CAS number: 100-52-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Numerous studies on the genotoxic potential of benzaldehyde are mentioned in the German MAK report on benzaldehyde (1998). In the following, only the most relevant studies for hazard assessment are presented.
Genotoxicity in vitro
The genotoxicity of benzaldehyde has been investigated in many in vitro lest systems. In Salmonella typhimurium, in mutagenicity studies with the strains TA98, TA100, TA102, TA104, TA1535, TA1537 and TA2637, and in a DNA repair lest with and without metabolic activation, no genotoxic activity could be detected. In a mutagenicity test with Escherichia coli WP2 uvrA and the mutagen 4-nitroquinoline-1-oxide, benzaldehyde from concentrations of 2120 µg/p1ate was found to have an antimutagenic effect (Watanabe et al. 1988). In Bacillus subtilis, DNA-damaging effects were observed at high concentrations only after metabolic activation. An increase in the incidence of mutants in the mause Iymphoma test occurred only in the high, cytotoxic concentration range and the finding is therefore questionable. Evidence of a weak clastogenic potential in the chromosomal aberration test and in the sister chromatid exchange test was also found only with high concentrations. Therefore there is merely evidence of weak genotoxic activity of benzaldehyde.
Genotoxicity in vivo
In the sex-linked recessive lethal test with Drosophila melanogaster, benzaldehyde administered in a concentration of 1500 ppm with the diet and injection of 2500 ppm was inactive (NTP 1990, Woodruff et al. 1985).
Endpoint Conclusion:
Justification for classification or non-classification
Based on the information on genotoxicity of benzaldehyde in vitro and in vivo, which outline, at most, only weak genotoxic activity,
no evidence is given for classification of benzaldehyde as mutagen according to Regulation (EU) 1272/2008 and Directive 67/548/EEC, respectively.
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