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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A dermal DL50 was conducted in which 10 rabbits received a dermal application of 5g/lg of the test material. The animals were observed for mortality and/or systemic effects for 14 days.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Cornmint oil
IUPAC Name:
Cornmint oil

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Duration of exposure:
14 days
Doses:
0.5 g/kg to 5 g/kg
No. of animals per sex per dose:
10 rabbits per dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
Distribution of mortality: no death within 14 days
Clinical signs:
Symptomatology: sloughing of skin 12 days post-dosage

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute dermal DL50 in rabbits is higher than 5 g/kg or 5000 mg/kg.bw.
According to the CLP Regulation, this DL50 does not trigger any classification as acutely toxic, dermal.