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EC number: 700-762-0 | CAS number: -
Justification for Read Across
Several criteria justify the use of the read across approach to fill data gaps for Category C isomerised olefins using tridecene as an analogue. Tridecene is an isomerised olefin; however, it is not a substance covered under the Higher Olefins and Poly Alpha Olefins Consortium. Therefore, tridecene’s chemical structure, as well as mammalian health endpoints, are comparable to other Category C isomerised olefins. Therefore, read across between tridecene and Category C isomerised olefins can be justified.
In an acute oral toxicity study, groups of young adult, fasted, albino rats (5 male, 5 female) were given a single oral dose of Neodene 13 Internal Olefin, at dose 5,000 mg/kg bw and observed for 14 days.
There were no treatment related clinical signs, necropsy findings or changes in body weight. The oral LD50 was determined to be 5,000 mg/kg bw in both males and females.
This study received a Klimisch score of one and is classified as reliable without restriction because the study was carried out according to or closely followed OECD 401 guideline and was GLP compliant. This study will influence the DNEL(s).
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