Titanium, (S)-lactate polyethylene glycol triisopropanolamine ammonium complexes

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Only limited details provided in NONS summary

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1989

Report date:

1989

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Annex V (Limit test)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

410-660-5

EC Name:

-

Cas Number:

1072830-14-8

Molecular formula:

Not Applicable for UVCB substance

IUPAC Name:

1-[bis(2-hydroxypropyl)amino]propan-2-ol 2-(rutherfordiooxy)ethan-1-ol 2-hydroxypropanoic acid amine titanium

Test animals

Species:

rat

Strain:

Sprague-Dawley

Administration / exposure

Vehicle:

water

Remarks:

Distilled water

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0

Clinical signs:

other: Signs of toxicity related to dose levels: No deaths and no signs of toxicity were observed

Gross pathology:

Effects on organs:
No treatment-related macroscopic findings were observed.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

LD50 concluded to be >5000mg/kg