Registration Dossier

Administrative data

Description of key information

Dienone did not show a skin irritating or corrosive potential but did produce a mild irritation effect in the eyes of rabbits. Based on data from the read across substance, dienone, didenac is not considered to be a skin irritant and is a mild eye irritant. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Read-across justification summary is attached to this endpoint summary.


Justification for selection of eye irritation endpoint:
Although substance may be slightly or mildly irritating, it's likely irritation is mechanical, rather than toxicological. Additionally, all the scores were low compared to the max score and reversible. Based on weight of evidence, didenac does not meet the criteria for classification as eye irritant.

Effects on eye irritation: slightly irritating

Justification for classification or non-classification

Based on read across to dienone, didenac is not classified as an eye irritant according to Directive 67/549 EEC and Regulation (EC) 1272/2008 (CLP).

Based on read across to dienone, didenac is not classifiable as a skin irritant according to Directive 67/548 EEC or Regulation (EC) 1272/2008 (CLP).