Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 610-545-1 | CAS number: 50588-42-6
Endpoint summary
Administrative data
Description of key information
Dienone did not show a skin irritating or corrosive potential but did produce a mild irritation effect in the eyes of rabbits. Based on data from the read across substance, dienone, didenac is not considered to be a skin irritant and is a mild eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Read-across justification summary is attached to this endpoint summary.
Justification for selection of eye irritation endpoint:
Although substance may be slightly or mildly irritating, it's likely irritation is mechanical, rather than toxicological. Additionally, all the scores were low compared to the max score and reversible. Based on weight of evidence, didenac does not meet the criteria for classification as eye irritant.
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
Based on read across to dienone, didenac is not classified as an eye irritant according to Directive 67/549 EEC and Regulation (EC) 1272/2008 (CLP).
Based on read across to dienone, didenac is not classifiable as a skin irritant according to Directive 67/548 EEC or Regulation (EC) 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
