Registration Dossier
Registration Dossier
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EC number: 941-237-8 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary data source, limited information about study.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Guideline:
- other: not mentioned
- Principles of method if other than guideline:
- Method followed unknown
- GLP compliance:
- no
Test material
- Reference substance name:
- Ammonium chloride
- EC Number:
- 235-186-4
- EC Name:
- Ammonium chloride
- Cas Number:
- 12125-02-9
- Molecular formula:
- ClH4N
- IUPAC Name:
- ammonium chloride
- Details on test material:
- Ammonium chloride Merck analytical grade, purity:unknown
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- other: without vehivle and in water
- Controls:
- not specified
- Amount / concentration applied:
- About 50 mg of the powdery product was applied to the conjunctival sac of the rabbit's eye. Both powder and aqueous solution were tested.
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- Observations after 10 minutes, 1 and 24 h and 8 days.
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- Comment: not rinsed
Results and discussion
In vivo
- Irritant / corrosive response data:
- -After 10min, 1 and 24hrs, clear signs of inflammation with redness, swelling and cloudy corneal opacity were observed.
-The changes were reversible within 8 days without leaving any residues. - Other effects:
- There were no differences in the irritation between the powder and aqueous solution.
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Classification: irritating for eyes.
Furthermore, ammonium chloride is officially classified under CLP criteria Eye Irrit. Cat. 4, H319: causes serious eye irritation (Annex VI table 3.1) and Xi, R36 (Annex VI table 3.2).
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