4,6-bis(octylthiomethyl)-o-cresol

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Remarks:

Type of genotoxicity: gene mutation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Year:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Annex V, B14

GLP compliance:

yes

Type of assay:

bacterial reverse mutation assay

Test material

Test material information

Constituent 1

Reference substance name:

4,6-bis(octylthiomethyl)-o-cresol

EC Number:

402-860-6

EC Name:

4,6-bis(octylthiomethyl)-o-cresol

Cas Number:

110553-27-0

Molecular formula:

C25H44OS2

IUPAC Name:

4,6-bis(octylthiomethyl)-o-cresol

Method

Species / strain

Species / strain / cell type:

bacteria, other: Salmonella Typhimurium, TA 98, TA 200, TA 1535 and TA 1537

Metabolic activation:

with and without

Metabolic activation system:

0.3 ml of S9 fraction of liver from rats (Tif: RAlf (SPF)) induced with Aroclor 1254 and 0.7 ml of a solution f co-factors.

Test concentrations with justification for top dose:

Concentration range in the main test (with metabolic activation): 20...5000 microg/plate
Concentration range in the main test (without metabolic activation): 20...5000 microg/plate

Vehicle / solvent:

solvent: acetone

Results and discussion

Test results

Species / strain:

other: Salmonella Typhimurium, TA 98, TA 200, TA 1535 and TA 1537

Metabolic activation:

with and without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

no cytotoxicity

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information):
negative without metabolic activation
negative with metabolic activation