Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 915-069-0
CAS number: -
In a NMRI
mouse bone marrow micronucleus assay according to OECD Guideline 474,
adopted May 26, 1983, EU method B.12, EEC Directive 84/449 and EPA,
Code of Federal Regulations, Title 40, Subpart F-Genetic Toxicology,
Revision July 1, 1986, groups of 6 mice per sex and bone marrow
harvest time were given a single oral dose of substance "reaction mass
of calcium hydrogen phosphonate and dialuminium tricalcium hexaoxide"
(90 % a.i.) in carboxymethylcellulose at a dose of 5000 mg/kg body
weight. Bone marrow cells were harvested at 24h, 48 h, and 72 h after
"reaction mass of calcium hydrogen phosphonate and dialuminium
tricalcium hexaoxide" (90 % a.i.) was tested at an adequate dose. In
pre-experiments this dose level was estimated to be the maximum
attainable dose. The animals expressed symptoms of indisposition
(reduced spontaneous activity, eyelid closure, apathy). The ratio
between PCEs and NCEs was not affected as compared to the
corresponding negative controls thus indicating no cytotoxic effects.
The positive controls did induce the appropriate response.
was no significant increase in the frequency of micronucleated
polychromatic erythrocytes in bone marrow after any treatment time.
study is classified as acceptable. This study satisfies the
requirement for Test Guideline OECD 474, EU Method B.12 and the EPA
Guideline for in vivo mammalian bone marrow cytogenetics tests
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again