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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Scientifically acceptable publication; however, the exposure period was reduced to only 90 minutes. Thus, there is not enough confidence to estimate the hazard potential to fish.

Data source

Reference
Reference Type:
publication
Title:
Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays
Author:
De Rosa, S., De Giulio, A. and Iodice, C.
Year:
1994
Bibliographic source:
Journal of Natural Products, Vol. 57, No. 12, pp. 1711-1716

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
A test guideline was not mentioned in the publication.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylhydroquinone
EC Number:
202-443-7
EC Name:
2-methylhydroquinone
Cas Number:
95-71-6
Molecular formula:
C7H8O2
IUPAC Name:
2-methylbenzene-1,4-diol
Constituent 2
Reference substance name:
Methylhydroquinone
IUPAC Name:
Methylhydroquinone
Details on test material:
- Origin of test material: Sigma-Aldrich s.r.l., Italy

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
yes
Details on test solutions:
PREPARATION OF TEST SOLUTION
- Test item was dissolved in Me2CO (1% final volume)

Test organisms

Test organisms (species):
Gambusia affinis
Details on test organisms:
- Common name: mosquito fish
- Weight of fish: 0.1 - 0.3 g

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
90 min

Test conditions

Nominal and measured concentrations:
- Concentrations tested (nominal): 100, 10, 1, 0.1, 0.01 and 0.001 ppm plus control
Details on test conditions:
TEST SYSTEM
- Replicates per concentration: 3
- Replicated per control: 2
- No. of fish per concentration: 6
- Introduction of organism to test medium: fish were placed in 70 mL of distilled H2O to which appropriate amounts of compound (dissolved in Me2CO) were added.

Results and discussion

Effect concentrations
Duration:
90 min
Dose descriptor:
LC50
Effect conc.:
38.5 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: 95% C.L.: 20.2-76.8 mg/L
Reported statistics and error estimates:
The data was statistically analyzed by the Finney program.

Applicant's summary and conclusion