Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 608-403-9 | CAS number: 297132-04-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation
- Remarks:
- other: in silico
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The substance contains 27% fragments that are unknown to the training set of the model.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- OASIS TIMES 2.27.13 TB, Skin sensitization v. 18.21 with autoxidation
- GLP compliance:
- no
- Type of study:
- other: QSAR
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
Reference
The parent was predicted to be a weak sensitizer. The prediction was indicated to be out of domain, because 27% of the fragments of the structure are unknown to the training set of the model.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
- Migrated from Short description of key information:
The substance is predicted to be a skin sensitizer by the QSAR model TIMES-SS. Although the structure contains 27% of unknown fragments and is therefore out the total domain of the model, it is considered sufficiently plausible for classification and labelling.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
