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Administrative data

Key value for chemical safety assessment

Additional information

1,4,6 -Trienol (ZK 5668) did not show a mutagenic potential in two experiments of a bacterial reverse mutation assay (S. typhimurim strains TA 1535, TA 1537, TA 98, TA 100 and TA 102) when tested up to the maximum recommended dose level of 5000 µg/plate in the absence and presence of extrinsic metabolic activation (liver S9 mix from phenobarbital/beta-naphthoflavone-treated rats). No cytotoxic effects were seen up to 5000 µg/plate. Precipitation of the test item was observed without metabolic activation in strains TA 1537 and TA 102 at 5000 µg/plate in the first experiment, and from 1000 µg/plate up to 5000 µg/plate in the second experiment.

Short description of key information:
Gene mutation (Ames-Test, OECD TG471): negative with and without metabolic activation
[Schering AG, Report No. X512 -draft-, 2001-01-30]

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on the results there is no classification required according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP).