1-methoxy-2-propanamine

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: comparable to OECD-guideline 404

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

609-333-1

EC Number:

609-333-1

Cas Number:

37143-54-7

Molecular formula:

C4 H11 N O

IUPAC Name:

609-333-1

Details on test material:

- Name of test material (as cited in study report): 1-methoxy-2-aminopropan

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Gaukler: D-6050 Offenbach/Main, FRG
- Weight at study initiation: 2.77 kg
- Housing: single; cage made of stainless steel with wire mesh walk floors, floor area: 40 cm x 51 cm
- Diet (e.g. ad libitum): KLIBA 341, 4 mm; Klingentalmuehle AG, CH-4303 Kaiseraugst, Switzerland; about 130 g per animal per day
- Water (e.g. ad libitum): tap water; about 250 ml per animal per day
- Acclimation period: at least 8 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12

Test system

Type of coverage:

semiocclusive

Preparation of test site:

other: fur was clipped

Vehicle:

unchanged (no vehicle)

Controls:

other: untreated skin of the same animal

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0,5 ml of undiluted test substance

Duration of treatment / exposure:

3 min and 1 h

Observation period:

24, 48 and 72 h

Number of animals:

1 male rabbit per exposure period

Details on study design:

TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm of untreated skin; upper third of the back or flanks
- Type of wrap if used: four layers of absorbent gauze + porous bandage

REMOVAL OF TEST SUBSTANCE
- Washing (if done): lutrol and lutrol/water (1:1)
- Time after start of exposure: 3 min and 1 h

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

other: animal #1 (3 min exposure)

Time point:

other: 24 - 48 - 72 h

Score:

4

Max. score:

4

Reversibility:

other: not applicable

Remarks on result:

other: individual scores: 4 - 4 - 4

Results 2

Irritation parameter:

erythema score

Basis:

other: animal #2 (1 h exposure)

Time point:

other: 24 - 48 - 72 h

Score:

4

Max. score:

4

Reversibility:

other: not applicable

Remarks on result:

other: individual scores: 4 - 4 - 4

Results 3

Irritation parameter:

edema score

Basis:

other: animal #1 (3 min exposure)

Time point:

other: 24 - 48 - 72 h

Score:

1

Max. score:

4

Reversibility:

other: not applicable

Remarks on result:

other: individual scores: 1 - 1 - 1

Results 4

Irritation parameter:

edema score

Basis:

other: animal #2 (1 h exposure)

Time point:

other: 24 - 48 - 72 h

Score:

2

Max. score:

4

Reversibility:

other: not applicable

Remarks on result:

other: individual scores: 2 - 2 - 2

Irritant / corrosive response data:

In both animals, the skin findings were irreversible within 72 h after the removal of the patches.

Other effects:

Both animals showed necrosis after 24 and 48 hours. After 72 h, both animals showed full thickness necrosis, which was confirmed by gross-pathology examination.

Applicant's summary and conclusion

Interpretation of results:

highly corrosive

Remarks:

Migrated information

Conclusions:

Under the conditions of the test, the substance has to be classified "highly corrosive" according to EU (R35) or GHS (Cat 1B) criteria.