Registration Dossier

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.18 mg/m³
Most sensitive endpoint:
acute toxicity
DNEL related information
Overall assessment factor (AF):
120
Modified dose descriptor starting point:
NOAEC

Local effects

Long term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
Most sensitive endpoint:
acute toxicity
Acute/short term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
Most sensitive endpoint:
skin irritation/corrosion

Workers - Hazard for the eyes

Additional information - workers

The results of investigations lead in interesting area, showing for the job investigated levels of exposure to pollutants sought (inhalable particulates and arsenic) is not significant. This might suggest that the concentrations of airborne arsenic doesn’t arise significantly from the values of environmental funds, which makes any actual assumption demonstrable basing on this hypothesis. No data is available for pyrite cinder or arsenic, therefore for calculation of the inhalation DNEL acute / short-term exposure - were considered systemicity actual values of the silica.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
Most sensitive endpoint:
acute toxicity
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.09 mg/m³
Most sensitive endpoint:
acute toxicity
DNEL related information
Overall assessment factor (AF):
240
Modified dose descriptor starting point:
NOAEC

Local effects

Long term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
Most sensitive endpoint:
acute toxicity
Acute/short term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
Most sensitive endpoint:
acute toxicity
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
Most sensitive endpoint:
skin irritation/corrosion
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
insufficient data available: testing proposed
Most sensitive endpoint:
skin irritation/corrosion

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.003 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
240
Modified dose descriptor starting point:
NOAEL
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.001 mg/kg bw/day
Most sensitive endpoint:
acute toxicity
DNEL related information
Overall assessment factor (AF):
240
Modified dose descriptor starting point:
NOAEL

General Population - Hazard for the eyes

Additional information - General Population

The results of investigations lead in interesting area, showing for the job investigated levels of exposure to pollutants sought (inhalable particulates and arsenic) is not significant. This might suggest that the concentrations of airborne arsenic doesn’t arise significantly from the values of environmental funds, which makes any actual assumption demonstrable basing on this hypothesis. No data is available for pyrite cinder or arsenic, therefore for calculation of the inhalation DNEL acute / short-term exposure - were considered systemicity actual values of the silica.