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Registration Dossier
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EC number: 204-463-1 | CAS number: 121-30-2
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- grey literature
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
- Principles of method if other than guideline:
- Test method not available.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-amino-6-chlorobenzene-1,3-disulphonamide
- EC Number:
- 204-463-1
- EC Name:
- 4-amino-6-chlorobenzene-1,3-disulphonamide
- Cas Number:
- 121-30-2
- Molecular formula:
- C6H8ClN3O4S2
- IUPAC Name:
- 4-amino-6-chlorobenzene-1,3-disulfonamide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Duration of treatment / exposure:
- six weeks
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 or 300 mg/kg bw
Basis:
nominal in diet
- Details on study design:
- In order to avoid an excessive salt depletion the rats had a supplement of potassium chloride in the drinking water on Sunday.
Results and discussion
Results of examinations
- Details on results:
- The rats grew normally, and autopsy with histological examination of the kidneys showed no pathological changes attribuitable to the diuretic.
Effect levels
- Sex:
- not specified
- Basis for effect level:
- other: The rats grew normally, and autopsy with histological examination of the kidneys showed no pathological changes attribuitable to the diuretic.
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The rats grew normally, and autopsy with histological examination of the kidneys showed no pathological changes attribuitable to the diuretic.
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