Registration Dossier
Registration Dossier
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EC number: 220-860-2 | CAS number: 2920-38-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
A SAR/(Q)SAR prediction performed with the OECD toolbox 2.2 (2011) based on an existing Danish EPA DB (Q)SAR model for skin sensitisation revealed no protein binding alerts in the parent structure. There were no data available for a category approach based on the relevant functional groups (arene, biphenyl, and nitrile).
In general, experimental data is considered to be more relevant than a theoretical prediction model. Nevertheless, based on OECD Toolbox prediction using Danish EPA DB (Q)SAR model for skin sensitisation, a skin sensitisation potential of the test item is not expected.
As seen on the ECHA dissemination view, neither benzontrile nor biphenyl are sensitizing. It is therefore unlikely that the p-phenylbenzotrile is sensitizing to skin.
Migrated from Short description of key information:
There are no data available concerning skin sensitisation. A SAR/(Q)SAR prediction of the test substance for skin sensitisation performed with the OECD Toolbox 2.2 (2011) affilliating an existing (Q)SAR model for skin sensitisation of the Danish EPA DB indicated no skin sensitising potential of the target substance.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No data available.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
There are no experimental test data available for skin sensitisation. Based on OECD Toolbox prediction using Danish EPA DB (Q)SAR model for skin sensitisation, a skin sensitisation potential of the test item is not expected. Therefore, classification for skin sensitisation under Directive 67/548/EEC is not warranted.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
There are no experimental test data available for skin sensitisation. Based on OECD Toolbox prediction using Danish EPA DB (Q)SAR model for skin sensitisation, a skin sensitisation potential of the test item is not expected. Therefore, classification for skin sensitisation under Regulation (EC) No.1272/2008 is not warranted.
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