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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only very little information is available. The information is based on an internal memorandum with a short summary of the results of a study report. The full study report is not available. Read-across justified in analogue reporting format.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1981

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
(RS)-2-[4-(5-Trifluoromethyl-2-pyridyloxy)phenoxy]propionic
EC Number:
614-949-9
Cas Number:
69335-91-7
Molecular formula:
C15H12F3NO4
IUPAC Name:
(RS)-2-[4-(5-Trifluoromethyl-2-pyridyloxy)phenoxy]propionic
Constituent 2
Reference substance name:
Propanoic acid, 2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenoxy]-
IUPAC Name:
Propanoic acid, 2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenoxy]-
Details on test material:
- IUPAC name: 2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy)propanoic acid
- Molecular formula: C15H12F3NO4
- Molecular weight: 327.26 g/mol
- Smiles notation: O=C(O)C(C)Oc1ccc(cc1)Oc2ccc(cn2)C(F)(F)F
- InChI=1/C15H12F3NO4/c1-9(14(20)21)22-11-3-5-12(6-4-11)23-13-7-2-10(8-19-13)15(16,17)18/h2-9H,1H3,(H,20,21)
The test substance is the racemate. It is a 1:1 mixture of the two enantiomers (2R)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid and (2S)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
other: test substance (racemate)
Other findings:
A slight irritant effect was observed during the course of the experiment.

Any other information on results incl. tables

Full information as given in the memorandum:

Acute dermal LD50 (rats) 5000 mg/kg

A slight irritant effect was observed during the course of the experiment.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Criteria used for interpretation of results: EU