Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 918-939-8 | CAS number: 1180558-15-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Short description of key information:
No data available for effects on fertility.
Effects on developmental toxicity
Additional information
Oral administration of 0.4, 2.0, 10.0, 25.0 and 50.0 mg/kg/day to pregnant rats from 7 days to day 17 of gestation produced no maternal or foetal effects in a preliminary teratogenicity study. The only available data is from a brief summarised secondary source, and as such is considered to be unreliable and inadequate for risk assessment and classification purposes. Information on a related substance is available from the harmonised classification and labelling listed in Annex VI to Regulation (EC) No. 1272/2008 (see classification justification).
Justification for classification or non-classification
The data described above are inadequate for classification and labelling. However the following information is relevant for classification and labelling of this substance:
Butyl (R)-2-[4-(5-trifluoromethyl-2-pyridyloxy) phenoxy]propionate (CAS No: 79241-46-6) is an active substance used in plant protection products.
(2R)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS No: 83066-88-0) is the major systemically available metabolite of the active substance.
In buffered biological systems, potassium (2R)-2-[4-[[5-trifluoromethyl-2-pyridinyl]oxy]phenoxy]propanoate will dissociate and form essentially the same chemical species as (2R)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid.
Butyl (R)-2-[4-(5-trifluoromethyl-2-pyridyloxy) phenoxy]propionate is listed in Regulation (EC) No. 1272/2008, Annex VI (Table 3.1: list of harmonised classification and labelling of hazardous substances and Table 3.2: list of harmonised classification and labelling of hazardous substances from Annex I to Directive 67/548/EEC) with Index No. 607-305-00-3.
The corresponding information on classification and labelling with respect to reproductive toxicity are:
Table 3.1: Repr. 2; H361d
Table 3.2: Repr. Cat. 3; Xn, R63
There is strong evidence to suggest that Butyl (R)-2-[4-(5-trifluoromethyl-2-pyridyloxy) phenoxy]propionate rapidly metabolizes in vivo to (2R)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid, thereby forming essentially the same chemical species as dissociated potassium (2R)-2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenoxy]propanoate. For this reason the corresponding classification and labelling with respect to reprotoxicity of the active substance is also adopted for potassium (2R)-2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenoxy]propanoate.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
