Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study, no data on GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Octylamine
EC Number:
203-916-0
EC Name:
Octylamine
Cas Number:
111-86-4
Molecular formula:
C8H19N
IUPAC Name:
octan-1-amine

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesam oil
Doses:
200/500/2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD0
Effect level:
200 mg/kg bw
Based on:
test mat.
Sex:
female
Dose descriptor:
LD0
Effect level:
200 mg/kg bw
Based on:
test mat.
Sex:
female
Dose descriptor:
LD100
Effect level:
500 mg/kg bw
Based on:
test mat.
Sex:
male
Dose descriptor:
other: LD80
Effect level:
500 mg/kg bw
Based on:
test mat.
Mortality:
200 mg/kg bw: 0/10
500 mg/kg bw: 9/10
2000 mg/kg bw: 10/10
Body weight:
normal body weight development in surviving animals.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
An acute oral toxicity study was performed per os with 5 rats/sex/dose according to OECD401.
The LD50 was found to be in the range of 200-500 mg/kg bw
Executive summary:

An acute oral toxicity study was performed per os with 5 rats/sex/dose according to OECD401.

The LD50 was found to be in the range of 200-500 mg/kg bw

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