Registration Dossier
Registration Dossier
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EC number: 606-280-6 | CAS number: 192704-54-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Diketon (ZK 233744) did not show a mutagenic potential in a bacterial reverse mutation assay (S. typhimurim strains TA 1535, TA 100, TA 1537, TA 1538 and TA98) when tested up to the maximum recommended dose level of 5 mg/plate in the absence and presence of extrinsic metabolic activation (liver S9 mix from Aroclor 1254 -treated rats). No Growth inhibition and no precipitates in the agar were observed up to 5.0 mg/plate.
Short description of key information:
Gene mutation (Ames-Test, OECD TG471): negative with and without metabolic activation
[Schering AG, Report No. X503 -draft-, 2001-01-30]
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the results there is no classification required according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP).
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