Registration Dossier
Registration Dossier
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EC number: 253-057-0 | CAS number: 36483-57-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Following a contact hypersensitivity to FR-513 in the mouse (LLNA), the simulation index (SI) values calculated for the test substance concentrations 1, 5 and 10% were 1.1, 1.1 and 0.9 respectively. There was no indication that the test substance could elicit SI ≥ 3.
Based on the study results and according to the criteria made in the test guidelines (OECD 429, OPPTS 870.2600) , FR-513 is not a skin sensitiser.
Migrated from Short description of key information:
Assessment of contact hypersensitivity to FR-513 in the mouse (Local Lymph Node Assay)
Justification for classification or non-classification
Based on the experimental results and according to the EEC criteria for classification and labelling requirements for dangerous substances and preparations (Guidelines in Commission Directive 93/21/EEC, 27th April 1993), FR-513 does not have to be classified and has no obligatory labelling requirement for acute toxicity .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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