Registration Dossier
Registration Dossier
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EC number: 937-559-3 | CAS number: 1360085-10-4
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- sodium 7-[(ethoxycarbonyl)amino]-4-hydroxynaphthalene-2-sulfonate
- EC Number:
- 937-559-3
- Cas Number:
- 1360085-10-4
- Molecular formula:
- C13H12NNaO6S
- IUPAC Name:
- sodium 7-[(ethoxycarbonyl)amino]-4-hydroxynaphthalene-2-sulfonate
- Details on test material:
- 85.2 % active substance
Constituent 1
Results and discussion
- Additional information on results:
- No toxic effects, evidenced by a reduction in the number of revertants, occurred in any of
the test groups with and without metabolic activation up to 5000.0 ug/plate.
The plates incubated with the test article showed normal background growth up to
5000.0 ug/plate with and without S9 mix in all strains used.
Reproducible, dose dependent increases in revertant colony numbers were observed in the
strain TA 98 following treatment with test substance in the presence of metabolic activation (S9 mix) in both experiments.
Any other information on results incl. tables
During the described mutagenicity test and under the
experimental conditions reported, the test article did induce gene mutations by frameshifts in
the genome of the strain TA 98.
Applicant's summary and conclusion
- Conclusions:
- The test substance is considered to be mutagenic in this Salmonella typhimurium reverse mutation assay.
- Executive summary:
Mutagenic in this Salmonella typhimurium reverse mutation assay.
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