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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979-05-01
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted standards with acceptable restrictions (limited documentation; raw data generally available on request)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Principles of method if other than guideline:
Method: other: no data
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyl(ethyl)amine
EC Number:
236-415-0
EC Name:
Butyl(ethyl)amine
Cas Number:
13360-63-9
Molecular formula:
C6H15N
IUPAC Name:
butyl(ethyl)amine
Details on test material:
- Name of test material (as cited in study report): N-Ethyl-N-n-butylamin; no further details

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose/head only
Vehicle:
air
Details on inhalation exposure:
no data
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
1 h
Concentrations:
2.45, 9.66, 10.18, and 11.87 mg/m3 (analytical)
No. of animals per sex per dose:
10
Control animals:
other: not required
Details on study design:
- Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: no data

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
10.6 mg/L air (analytical)
Exp. duration:
1 h
Sex:
female
Dose descriptor:
LC50
Effect level:
> 11.9 mg/L air (analytical)
Exp. duration:
1 h

Any other information on results incl. tables

 

Concentration

(mg/L; analytical

Mortality

No. dead /No. exposed

Male

female

2.45

0/10

0/10

9.66

2/10

0/10

10.18

5/10

0/10

11.87

8/10

0/10

 

Applicant's summary and conclusion

Executive summary:

10 male and female Wistar rats were exposed (head-nose only) to Butylethylamine for 1 hour at analytical concentrations of 2.45 to 11.87 mg/L. All females survived whereas male mortality increased with dose up to 80% at the top dose. The LC50(1hr)was 10.6 mg/L for the male rat (BASF, 1979).

The study may be used for assessment using the LC50, 1 -hr -value for male rats. There is no explanation why no deaths occurred in females.