Registration Dossier
Registration Dossier
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EC number: 236-415-0 | CAS number: 13360-63-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Ethylbutylamine is corrosive to the skin, and therefore skin sensitisation testing is not allowed according to REACH, Annexes VII and VIII, section 8.1, column 2. Skin protection is required to protect against skin corrosion and irritation, and this will also protect against sensitisation in the unlikely case that the substance should possess a weak sensitising potential.
Skin necrosis and irritation but no sensitisation (0%) was seen in a Magnusen Kligman study with Guinea pigs. Due to methodological deficiencies (insufficient number of test and control animals; skin corrosion; no positive control substance included) the study is considered to be invalid (Safepharm, 1980).
Migrated from Short description of key information:
The substance is not sensitising. Skin necrosis and irritation but no sensitisation (0%) was seen in a Magnusen Kligman study with Guinea pigs.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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