Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Information from migrated NONS file, as per inquiry number 06-2120017060-79-0000, permission to refer granted by ECHA
Title:
Unnamed
Year:
1996
Report date:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
421-450-8
EC Name:
-
Cas Number:
154702-15-5
Molecular formula:
C44H59N7O5
IUPAC Name:
2-ethylhexyl 4-[(4-{[4-(tert-butylcarbamoyl)phenyl]amino}-6-[(4-{[(2-ethylhexyl)oxy]carbonyl}phenyl)amino]-1,3,5-triazin-2-yl)amino]benzoate

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: isotonic saline
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
4 hours
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Remarks:
mean score
Time point:
other: overall at 24, 48 and 72 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #2
Remarks:
mean score
Time point:
other: overall at 24, 48 and 72 hours
Score:
0
Irritation parameter:
erythema score
Basis:
animal #3
Remarks:
mean score
Time point:
other: overall at 24, 48 and 72 hours
Score:
0
Irritation parameter:
erythema score
Max. score:
0
Remarks on result:
other: Maximum value at the end of observation period : 0 (related to all animals)
Irritation parameter:
edema score
Basis:
animal #1
Remarks:
mean score
Time point:
other: overall at 24, 48 and 72 hours
Score:
0
Irritation parameter:
edema score
Basis:
animal #2
Remarks:
mean score
Time point:
other: overall at 24, 48 and 72 hours
Score:
0
Irritation parameter:
edema score
Basis:
animal #3
Remarks:
mean score
Time point:
other: overall at 24, 48 and 72 hours
Score:
0
Irritation parameter:
edema score
Max. score:
0
Remarks on result:
other: Maximum value at the end of observation period : 0 (related to all animals)

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Conclusions:
The test substance is not irritating to rabbit skin.