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Registration Dossier
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EC number: 202-225-1 | CAS number: 93-17-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study (OECD 404). Non GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Method: according to Fed. Reg. 38 (187), §1500.41, p. 27029, 27-Sep-1973
- GLP compliance:
- no
Test material
- Reference substance name:
- veratrylcyanid
- IUPAC Name:
- veratrylcyanid
- Reference substance name:
- 78/834
- IUPAC Name:
- 78/834
- Details on test material:
- Veratrylcyanid; no data on purity given in the report
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- - source: Gaukler
- number of animals: 2 males and 4 females
- mean body weights [kg] at application time: 2.8 (males) and 2.52 (females)
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- water
- Controls:
- other: untreated skin of the animals
- Amount / concentration applied:
- - Concentration: 50 %
- amount: ca. 0.5 g
- area of application: 2.5 x 2.5 cm - Duration of treatment / exposure:
- 24 h
- Observation period:
- 8 days
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- other: animal #1, #2, #3, #4, #5, #6
- Time point:
- other: 24 , 48 . 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: individual scores: 0 - 0 - 0
- Irritation parameter:
- erythema score
- Basis:
- other: animal #1, #2, #3, #4 and #5
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: individual scores: 1 - 0 - 0
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: individual scores: 0 - 0 - 0
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
- Conclusions:
- Based on the results of this study, the test substance veratrylcyanid does not have to be classified according to Regulation (EU) 1272/2008 and Directive 67/548/EEC.
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