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EC number: 211-951-8 | CAS number: 719-80-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted may 12th, 1981
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl diphenylphosphinite
- EC Number:
- 211-951-8
- EC Name:
- Ethyl diphenylphosphinite
- Cas Number:
- 719-80-2
- Molecular formula:
- C14H15OP
- IUPAC Name:
- ethyl diphenylphosphinite
- Details on test material:
- - Name of test material (as cited in study report): Diphenylethoxyphopsphin
- Physical state: liquid
- Expiration date of the lot/batch: 10/1982
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach
- Age at study initiation: app. 12 weeks
- Weight at study initiation: 180g on average
- Fasting period before study: 16h (water ad lib.)
- Housing: in groups of 5 in V-II-A-meshed steel cages, type DK-III
- Diet (e.g. ad libitum): SSNIFF
- Water (e.g. ad libitum): VE water or tap water (only on holidays) ad lib.
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-26°C
- Humidity (%): 45 - 75%
- Air changes (per hr): 15-20
- Photoperiod (hrs dark / hrs light): 12h/12h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% CMC in water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 6.81; 4.64; 3.16; 2.15% (w/v)
- Amount of vehicle (if gavage): 10ml/kg b.w.
- Justification for choice of vehicle: aqueous solution comparable to physiological media
MAXIMUM DOSE VOLUME APPLIED: 10ml/kg b.w. - Doses:
- 681mg/kg
464mg/kg
316mg/kg
215mg/kg - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: >15min, 15min, 30min, 1h, 2h, 4h, and 5h after application, twice daily on workdays and daily on holidays thereafter
- Frequency of weighing: day 0, 2, 7, 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology of findings during gross pathology - Statistics:
- LD50 (m+f) calculated according to Finney, D.J., probit analysis, cambridge university press, 1971
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 316 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 681 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 456 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 357 - < 650
- Mortality:
- Males
681mg/kg: 3 animals died within 24h, no mortality occured in any other test group
Females
681mg/kg, 464mg/kg: all except one animal of the highest dose died within 24h, the last animal died within 2days
316mg/kg: 2 animals died within 24h
215mg/kg: 1 animal died within 24h - Clinical signs:
- Dyspnoe, apathy, staggering gait, impaired general state in all groups
abnormal position, atony, tonic cramps, piloerection, exsiccosis , exophthalmus in some groups
no corneal reflex, no pain reflex, anaesthesia-like state in females in the two mid dosages
for details see tables 1 and 2 under additional information - Body weight:
- normal weight gain in all male survivers
stagnation in females up to day 2, normal weight gain thereafter - Gross pathology:
- Discoloration (whitish grey to clay colored) of liver and kidney in animals found dead.
Marks on the peripheral lobuli of the liver in 2 surviving male animals receving 464mg/kg, diagnosed as lipophanerosis during histopathological examination.
No further abnormalities were noted.
Any other information on results incl. tables
Table 1
Males | ||||
681mg/kg | 464mg/kg | 316mg/kg | 215mg/kg | |
Dyspnoe | 15m-2d | 15m-2d | 15m-2d | 15m-2d |
Apathy | 15m-2d | 15m-2d | 15m-2d | 15m-2d |
abnormal position | 1h-5h | 2h-1d | ||
staggering gait | 30m-2d | 30m-2d | 30m-2d | 30m-5h |
Atony | 1h-5h | 2h-1d | ||
tonic cramps | 2h-5h | 2h-5h | ||
piloerection | 30m-6d | 2h-6d | 2d-7d | |
exsiccosis | 1h-5h | 2h-2d | 1d-2d | |
exophthalamus | 2h-5h | 2h | ||
impaired general state | 15m-2d | 15m-2d | 15m-2d | 15m-2d |
Table 2 | ||||
Females | ||||
681mg/kg | 464mg/kg | 316mg/kg | 215mg/kg | |
Dyspnoe | 15m-1d | 15m-5h | 15m-2d | 15m-2d |
Apathy | 15m-1d | 15m-5h | 15m-2d | 15m-2d |
abnormal position | 1h-5h | 1h-5h | 2h-1d | |
staggering gait | 30m-1d | 30m-5h | 30m-2d | 30m-2d |
Atony | 15m-1d | 1h-5h | 2h-1d | |
no pain reflex | 2h | 2h | ||
no corneal reflex | 2h | 2h | ||
anaesthesia-like state | 2h | 2h | ||
tonic cramps | 2h-5h | 2h-5h | ||
piloerection | 30m-5h | 2h-5h | 2h-6d | 2h-6d |
exsiccosis | 2h-5h | 1h-5h | 2h-2d | 2d |
exophthalamus | 2h-5h | 2h-5h | 2h-1d | |
impaired general state | 15m-1d | 15m-5h | 15m-2d | 15m-2d |
m: minute, h: hour, d: day
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
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