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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

rabbit, 4h, occlusive (BASF 1982, according to OECD 404): slight irritant
rabbit: substance not washed out (BASF 1982, OECD 405): not irritant

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information


In an acute dermal irritation/corrosion study according to OECD 404, 0.5 ml of the test substance were topically applied to the intact skin of 3 White Vienna rabbits for 4 hours under occlusive conditions (BASF 1982). The average score (24 to 72 hours) for irritation was 1.6 (2 rabbits and 1.3 (1 rabbit) for erythema and 1.3, 0.6, 0.3 for edema, thus the test substance was only slightly irritating in this assay. All skin reactions were reversible within 8 days at the latest.


3 white Vienna rabbits were subjected to a single ocular application of 0.1ml of the test substance in a study according to OECD 405 (BASF AG 1982) . The substance was not washed out and effects on the eyes were scored according to Draize. No effects on the iris, the cornea and no chemosis were oberserved in all animals after 24, 48, and 72h (score = 0). Conjunctival redness was observed after 24 and 48h, but not anymore after 72h. The mean score (24h-72h) was 0.6 for 2 rabbits and 1 for the third animal.

Justification for classification or non-classification

The available data on ethyl diphenylphosphinite indicate only a slight irritating potential to the skin and almost no irritating potential to the eye. The scores obtained in the in vivo tests do not justify classification according to 67/548/EEC or CLP/EU-GHS.